The pharmacokinetics, metabolism and tissue distribution of tinidazole

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Abstract
The pharmacokinetics of tinidazole after single and multiple intravenous and oral doses are reviewed. Typically, a 2 g single oral dose provides peak drug concentrations in the plasma of c . 40 mg/l, declining to c . 10 mg/l at 24 h and c . 25 mg/l at 48 h. Daily maintenance doses of 1 g po maintain drug concentrations above 8 mg/l throughout the treatment period. Intravenous doses produce similar plasma concentrations, after allowing for the differences in dose; infusions of 800 mg at 24 h intervals maintain drug concentrations above 5 mg/l throughout treatment. Studies in animals with radiolabelled tinidazole showed that radioactivity is readily taken up and cleared from most body tissues. For man, more than adequate antimicrobial concentrations have been demonstrated in key tisues—those of the gastrointestinal tract, the genital tract, the buccal cavity and the CSF, following the clinically recommended dosage regime.

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