Effect of Dextran Infusion on Left Atrial Size in Normal Subjects

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Abstract
The purpose of this study was to evaluate left atrium dimension during acute volume loading. Low molecular weight dextran solution (1,000 ml) was continuously infused in 10 subjects without cardiac disease. Measurements of pulmonary arterial, capillary wedge, right atrial and systemic blood pressures, cardiac output, heart rate and M-mode left atrial maximum diameter were made in basal conditions and after 250, 500, 750 and 1,000 ml of dextran. In 4 subjects a two-dimensional echocardiogram was also obtained in the short axis and four-chamber views. Dextran produced the following changes (mean values ± standard deviation) in haemodynamic variables: right atrial and wedge pressures increased from 3.2 ± 1.55 to 12.3 ± 3.08 mm Hg (p

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