Effect in Vitro of 3-Hydroxy-3-Methylglutaric Acid on the Synthesis of Mevalonate and Its Precursors
- 1 January 1977
- journal article
- Published by Taylor & Francis in Archives Internationales de Physiologie et de Biochimie
- Vol. 85 (1) , 1-10
- https://doi.org/10.3109/13813457709069849
Abstract
Addition of 3-hydroxy-3-methylglutaric acid (free HMG) to supernatant-microsomal preparation decreased the synthesis of acetoacetate, HMG-CoA and mevalonolactone by 12%, 33% and 75%, respectively, from [2-14C] acetate. Free HMG also inhibited the activity of HMG-CoA reductase in the microsomes. It is concluded that HMG, apart from inhibiting the activity of HMG-CoA reductase (the rate limiting enzyme in cholesterogenesis) also interferes with the enzymatic steps involved in the conversion of acetate to HMG-CoA.Keywords
This publication has 17 references indexed in Scilit:
- Studies on the hypolipidemic and hypocholesterolemic effect of 3-hydroxy-3-methylglutaric acid in rabbitsAtherosclerosis, 1974
- 3-Hydroxy-3-methylglutaric acid: Protective action in experimental atherosclerosis in rabbitsAtherosclerosis, 1973
- EFFECTIVENESS OF 3-HYDROXY-3-METHYLGLUTARIC ACID IN FAMILIAL HYPERCHOLESTEROLÆMIAThe Lancet, 1973
- Hepatic acetate levels in relation to altered lipid metabolismMetabolism, 1973
- Hepatic acetic thiokinase: Possible regulatory step in lipogenesisMetabolism, 1972
- In vitro and in vivo inhibition of hepatic cholesterol synthesis by 3-hydroxy-3-methylglutaric acidBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1972
- Biosynthesis of 3-hydroxy-3-methylglutarate and mevalonate by rat liver homogenates in vitroBiochemistry, 1970
- [62] Separation of citric acid cycle and related compounds by partition column chromatographyPublished by Elsevier ,1969
- Effect of 3-hydroxy-3-methylglutaric acid on blood lipids in normal and cholesterol-fed ratsCellular and Molecular Life Sciences, 1968
- Hypocholesterolemic effect of 3-hydroxy-3-methylglutaric acidCellular and Molecular Life Sciences, 1967