Leukotriene Receptors
- 1 January 1989
- journal article
- review article
- Published by Taylor & Francis in Journal of Receptor Research
- Vol. 9 (4-5) , 341-367
- https://doi.org/10.3109/10799898909066063
Abstract
Leukotrienes are metabolites of arachidonic acid catalyzed by a novel lipoxygenase specific for the C-5 position. These fatty acids have many pharmacological properties including smooth muscle contractions and leukocytes activation, and are believed to play a key role in inflammatory and hypersensitivity reactions. Experimental evidence suggests that the action of leukotrienes is mediated by specific receptors. In this paper pharmacological and biochemical data in favor of the existence of leukotriene receptors are presented and hypotheses on the mechanisms of action and transduction are discussed.This publication has 107 references indexed in Scilit:
- Stimulation by leukotriene D4 of increases in the cytosolic concentration of calcium in dimethylsulfoxide-differentiated HL-60 cells.Journal of Clinical Investigation, 1987
- Identification and characterization of leukotriene C4 and D4 receptors on a cultured smooth muscle cell line BC3H-1Life Sciences, 1987
- Specific binding of leukotriene B4 to guinea pig lung membranesBiochemical and Biophysical Research Communications, 1987
- High-affinity binding site for leukotriene C4 in human erythrocytesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1986
- Detergent solubilization of human neutrophil leukotriene B4 receptorsBiochemical and Biophysical Research Communications, 1985
- Effect of the serine-borate complex on the relative ability of leukotriene C4, D4 and E4 to inhibit lung and brain [3H]leukotriene D4 and [3H]leukotriene C4 binding: Demonstration of the agonists' potency order for leukotriene D4 and leukotriene C4 receptorsBiochemical and Biophysical Research Communications, 1984
- Identification of leukotriene D4 receptor binding sites in guinea pig lung homogenates using [3H]leukotriene D4Biochemical and Biophysical Research Communications, 1984
- Agonist specific desensitization of leukotriene C4-stimulated PGI2 biosynthesis in human endothelial cellsBiochemical and Biophysical Research Communications, 1983
- Peptidoleukotrienes: Distinct receptors for leukotriene C4 and D4 in the Guinea-pig lungBiochemical and Biophysical Research Communications, 1983
- Evidence for multiple leukotriene D4 receptors in smooth muscleLife Sciences, 1982