Central site for pressor action of blood-borne angiotensin in rat

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Abstract
The threshold dose of intra-arterial angiotensin II required to induce a pressor response in the rat was significantly lower when the drug was administered into the carotid artery than when administered into the abdominal aorta. Part of the increase in arterial pressure produced by low concentrations of blood-borne angiotensin in this species was the result of an effect on structures in the CNS selectively accessible via the carotid vascular bed. The site of the pressor action of angiotensin was established more precisely within the CNS. The central component of the pressor effect of angiotensin was quantified as the difference in pressor responses to intracarotid and intra-aortic infusions of angiotensin II (.DELTA.c-a). In conscious rats, .DELTA.c-a was attenuated by administration of the angiotensin antagonist, saralasin, into the 3rd cerebral ventricle. In rats with chronic electrolytic lesions of the antroventral 3rd ventricle (AV3V), .DELTA.c-a was abolished. Periventricular structures surrounding the 3rd ventricle appear to mediate the central component of the pressor action of blood-borne angiotensin in the rat.

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