Mannitol diuresis in hemorrhagic hypotension

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Abstract
In anesthetized dogs and cats bleeding to arterial pressures below 50 mm Hg did not cause anuria when infusions of hypertonic mannitol were given at 0.20–0.40 ml/kg·min. In animals infused with isotonic saline, urine flow stopped below 50 mm Hg, but could be re-established by infusion of hypertonic solutions of mannitol, sodium sulfate, or urea. In both groups urine flow finally stabilized at 5–40%, and GFR (CIn) at 2–14% of prehemorrhagic values. CCr(exog)/CIn fell to values below unity in hemorrhagic hypotension in most dogs. In most cats CCr(exog) /CIn was larger than 1.10, and was lowered in hemorrhagic hypotension.