Reduced Level of Cellular Glucocorticoid Receptors in Patients with Anorexia Nervosa

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Abstract
Specific glucocorticoid receptors were measured in circulating mononuclear leukocytes from 12 patients with anorexia nervosa and 21 healthy control subjects. Cells from patients were found to contain a significantly (p < 0.01) lower level of glucocorticoid receptor (3830 ± 210 sites/cell, mean ± SE) than those from controls (4930 ± 250 sites/cell). A partial glucocorticoid receptor defect may well explain the abnormal cortisol metabolism and glucocorticoid resistance commonly found in patients with anorexia nervosa.

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