OBSERVATIONS ON THE ANTIGENICITY AND CLINICAL EFFECTS OF A CANDIDATE ANTI-PREGNANCY VACCINE - BETA-SUBUNIT OF HUMAN CHORIONIC-GONADOTROPIN LINKED TO TETANUS TOXOID

  • 1 January 1980
    • journal article
    • research article
    • Vol. 34  (4) , 328-335
Abstract
Observations on the antibody response and clinical effects of injection of purified .beta.-subunit of human chorionic gonadotropin covalently linked to tetanus toxoid were made in 15 healthy young women who had previously undergone tubal ligation. Antibodies detectable by radioimmunoassay were found in 14 of the women. Clinical surveillance and immunologic, hematologic and biochemical tests indicated excellent local and systemic tolerance to the antigen. No significant adverse effects on menstrual function, endocrine status, or health were found.