IgE in Human Urine and Milk

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Abstract
Ig[immunoglobulin]E was found in urine from healthy adult volunteers at very low levels (approximately 0.003-0.010 IU/ml), corresponding to a 24 h excretion rate of 3-16 IU. IgE was not detected in 36 out of 47 samples of milk and colostrum. In samples from 6 women, the protein was present at low concentration 1-2 days postpartum but was not detected in later samples (usually day 5 or 6). Mammary secretions from 4 allergic donors were studied, and IgE was detected at low concentrations in samples from the 2 most severely affected individuals. The levels of IgE observed in urine and milk suggest that there is no significant synthesis of the protein in either the urinary tract or in mammary tissue.

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