Experimental Stress Ulcers in Acidotic and Nonacidotic Renal Insufficiency

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Abstract
Stress ulcers are a frequent complication in patients with renal insufficiency. Rats were used to study the effect of renal insufficiency on restraint-induced stress ulcer formation. Acidotic, hyperkalemic renal insufficiency produced by the nephrotoxin uranyl nitrate and nonacidotic, normokalemic renal insufficiency produced by partial nephrectomy followed by internal contralateral nephrectomy enhance restraint-induced gastric erosions and ulcers. These studies demonstrate that both acute renal insufficiency with its concomitant acidosis and hyperkalemia and uremia enhance restraint-induced stress ulcer formation, possibly by impairing the normal reparative process of the gastric mucosa.