Selective Inhibition of Cough and Bronchoconstriction in Conscious Guinea Pigs
- 1 January 1992
- journal article
- Published by S. Karger AG in Respiration
- Vol. 59 (2) , 72-76
- https://doi.org/10.1159/000196030
Abstract
In guinea-pigs citric acid-induced cough and bronchoconstriction were inhibited by beta 2-agonist and xanthine drugs. Lidocaine inhibited only cough. Cromoglycate and ipratropium bromide inhibited only bronchoconstriction. We conclude that cough and bronchoconstriction in guinea-pigs are distinct reflexes and that the inhibitory pharmacology of these airway reflexes may agree in many respects, with that observed in asthmatic subjects.Keywords
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