The Selective Advantage of an Adenineless Double Mutant Over One of the Single Mutants Involved

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Abstract
In 3 stock cultures of an adenineless, purple strain of Neurospora, a 2d spontaneous mutation to adenineless occurred. Each of the resulting double mutants prevented the accumulation of purple pigment and showed a selective advantage over the single mutant in faster initial growth rate and greater mycelial dry wts. In mixed cultures of the purple strain and any of the double mutants the growth rate was the same as that of the double mutant and no pigment was formed, indicating that the purple strain was forced out early in growth. Crosses with wild type and 4 induced adenineless mutants indicated that the 3 spontaneous mutants were genetically distinct.

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