Xanthocyclines: 5-oxaanthracyclines (7,8,9,10-tetrahydrobenzo[b]xanthen-12-one)
- 1 August 1982
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 60 (15) , 1996-2001
- https://doi.org/10.1139/v82-281
Abstract
The anthracycline antibiotics daunorubicin and adriamycin are potent antitumor agents. It has recently been suggested that 5-oxaanthracycline analogs of these compounds might show reduced cardiotoxicity, a property that limits the clinical use of the anthracyclines. In this paper we describe the condensation–cyclization reactions of 2-methylchromone-3-carboxylate with cyclohexanones, a reaction that leads ultimately to the xanthocycline skeleton.This publication has 5 references indexed in Scilit:
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