Inhibition of clinical isolates of human cytomegalovirus and varicella zoster virus by PNU‐183792, a 4‐oxo‐dihydroquinoline

Publisher Website
Google Scholar
Abstract
The susceptibility of human cytomegalovirus (CMV) and varicella zoster virus (VZV) clinical isolates to PNU‐183792, a 4‐oxo‐dihydroquinoline, was examined. The antiviral potency of PNU‐183792, a non‐nucleoside inhibitor, was compared to the licensed nucleoside inhibitors ganciclovir and acyclovir using plaque reduction and virus yield reduction assays. PNU‐183792 was as potent against CMV as ganciclovir and was superior in potency to acyclovir against VZV. PNU‐183792 represents a new class of non‐nucleoside inhibitors of human herpesviruses. J. Med. Virol. 68: 234–236, 2002.