β-Thalassemia intermedia Homozygous for Normal Hemoglobin A2 β-Thalassemia

Abstract
Four homozygotes for .beta.-thalassemia with normal Hb A2 and F were studied. The absence or scarcity of transfusion requirement and comparatively low Hb F content were the most important findings. Both parents of 3 patients showed the findings of .beta.-thalassemia with normal Hb A2 and F. Two patients and their parents showed moderate or mild .beta.-chain deficiency. The possible reason for this comparatively mild course of a .beta.-thalassemia syndrome lies in a mild deficit in .beta.-chain production.

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