Cholesterol as a carcinogen
- 13 August 1957
- journal article
- research article
- Published by The Royal Society in Proceedings of the Royal Society of London. B. Biological Sciences
- Vol. 147 (926) , 84-89
- https://doi.org/10.1098/rspb.1957.0037
Abstract
In confirmation of previous reports from this Institute, cholesterol has been shown to be carcinogenic. Highly purified cholesterol (Schwenk process), dissolved in olive oil by heating on the water-bath, was injected subcutaneously into 224 stock mice. Fourteen sarcomas were induced at the site of injection. In one group of these mice, eleven sarcomas arose in 115 mice, the percentage when calculated on the number of mice which survived to at least the minimal latent period being 14%. There is no evidence that purification impairs the carcinogenic potency of cholesterol.Keywords
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