The Heritable Translocation Assay: Its relationship to assessment of genetic risk for future generations
- 1 January 1981
- journal article
- research article
- Published by Wiley in Teratogenesis, Carcinogenesis, and Mutagenesis
- Vol. 1 (3) , 305-332
- https://doi.org/10.1002/tcm.1770010307
Abstract
The Heritable Translocation Assay (HTA) is an in vivo mammalian mutation test which measures specific clastogenic damage. It can be subjected to rigorous statistical scrutiny and detects a type of heritable genetic damage that is known to contribute to the human disease burden. Because of these factors the HTA is one of the major tests of the battery used in regulatory evaluation of potential environmental mutagens. Although tests for detecting inherited translocations have been developed and improved over the past 40 years, further emphasis on several statistical considerations affecting the precision and reliability of HTA animal model data applied to regulatory hazard evaluation and risk assessment seems warranted. In this paper we have presented a brief history and the basic methodology for the HTA. Statistical concepts related to the design and implementation of HTA studies, such as the incorporation of false classification error probabilities in determination of required sample size and use of the single sample binomial versus Fisher's exact test for analysis of data, have been examined in detail. We have also suggested a simplified method of extrapolating HTA animal data to man similar to that used with carcinogenesis data and propose other developmental needs and perspectives for application of this assay to regulatory assessment of environmental mutagens.Keywords
This publication has 59 references indexed in Scilit:
- New approaches to mutagenicity studies in animals for carcinogenic and mutagenic agents. I. Modification of the heritable translocation testTeratogenesis, Carcinogenesis, and Mutagenesis, 1981
- Dominant cataract mutations induced by γ-irradiation of male miceMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1979
- Heritable translocation test on random-bred mice after prolonged triethylenemelamine treatmentMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1978
- Mutagenicity studies on rats and mice given canned, heated, nitrite-treated porkMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1977
- Heritable translocation test and dominant-lethal assay in male mice with methyl methanesulfonateMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1977
- Mutagenicity tests with aflatoxins in the mouseMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1975
- Mutagenicity tests with mebendazole in the mouseMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1974
- An approach to measuring germinal mutations in the mouse.Environmental Health Perspectives, 1973
- Estimates of the genetic risks from ionizing irradiationMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1971
- A New Mutant in the Progeny of Mice Treated with Nitrogen MustardNature, 1949