Role of the IGF‐I receptor in the regulation of cell–cell adhesion: Implications in cancer development and progression
- 11 December 2002
- journal article
- review article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 194 (2) , 108-116
- https://doi.org/10.1002/jcp.10207
Abstract
The insulin‐like growth factor‐I receptor (IGF‐IR) is a ubiquitous multifunctional tyrosine kinase that has an important role in normal cell growth and development. However, abnormal stimulation of IGF‐IR signaling has been implicated in the development of different types of tumors. The strong antiapoptotic activity of IGF‐IR has been recognized as critical in IGF‐I‐dependent tumorigenesis, however, the impact of other IGF‐IR functions, such as regulation of cell–cell and cell–matrix adhesion are also increasingly acknowledged. Here, on the model of breast cancer cells, we discuss how IGF‐IR‐dependent regulation of intercellular adhesion may affect cell survival, resistance to antiestrogens, and invasion.Keywords
This publication has 103 references indexed in Scilit:
- C-Cadherin Ectodomain Structure and Implications for Cell Adhesion MechanismsScience, 2002
- Identification of Insulin Receptor Substrate 1 (IRS-1) and IRS-2 as Signaling Intermediates in the α6β4 Integrin-Dependent Activation of Phosphoinositide 3-OH Kinase and Promotion of InvasionMolecular and Cellular Biology, 2001
- Anti-apoptotic Signaling of the Insulin-like Growth Factor-I Receptor through Mitochondrial Translocation of c-Raf and Nedd4Journal of Biological Chemistry, 2001
- Insulin and IGF-1 stimulate the β-catenin pathway through two signalling cascades involving GSK-3β inhibition and Ras activationOncogene, 2001
- Cadherin/catenin complex: A target for antiinvasive therapy?Journal of Cellular Biochemistry, 1996
- Cadherin-Mediated Adhesion Is Required for Normal Growth Regulation of Human Gingival Epithelial CellsCell Adhesion and Communication, 1996
- c-erbB-2 Gene Product Associates with Catenins in Human Cancer CellsBiochemical and Biophysical Research Communications, 1994
- The prognostic value of insulin-like growth factor-I in breast cancer patients. Results of a follow-up study on 126 patientsEuropean Journal Of Cancer, 1994
- Type 1 IGF receptor in human breast diseasesBreast Cancer Research and Treatment, 1992
- CADHERINS: A MOLECULAR FAMILY IMPORTANT IN SELECTIVE CELL-CELL ADHESIONAnnual Review of Biochemistry, 1990