Cofilin Promotes Actin Polymerization and Defines the Direction of Cell Motility
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- 30 April 2004
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 304 (5671) , 743-746
- https://doi.org/10.1126/science.1094561
Abstract
A general caging method for proteins that are regulated by phosphorylation was used to study the in vivo biochemical action of cofilin and the subsequent cellular response. By acute and local activation of a chemically engineered, light-sensitive phosphocofilin mimic, we demonstrate that cofilin polymerizes actin, generates protrusions, and determines the direction of cell migration. We propose a role for cofilin that is distinct from its role as an actin-depolymerizing factor.Keywords
This publication has 25 references indexed in Scilit:
- A New Strategy for Caging Proteins Regulated by KinasesJournal of the American Chemical Society, 2002
- Stromal Cell-Derived Factor 1α Activates LIM Kinase 1 and Induces Cofilin Phosphorylation for T-Cell ChemotaxisMolecular and Cellular Biology, 2002
- Cofilin Produces Newly Polymerized Actin Filaments that Are Preferred for Dendritic Nucleation by the Arp2/3 ComplexCurrent Biology, 2002
- How is actin polymerization nucleated in vivo?Trends in Cell Biology, 2001
- Role of Cofilin in Epidermal Growth Factor–Stimulated Actin Polymerization and Lamellipod ProtrusionThe Journal of cell biology, 2000
- Relationship between Arp2/3 Complex and the Barbed Ends of Actin Filaments at the Leading Edge of Carcinoma Cells after Epidermal Growth Factor StimulationThe Journal of cell biology, 1999
- Overexpression of cofilin stimulates bundling of actin filaments, membrane ruffling, and cell movement in Dictyostelium.The Journal of cell biology, 1996
- Concentration of cofilin, a small actin‐binding protein, at the cleavage furrow during cytokinesisCell Motility, 1995
- Cytoplasmic Localization and Nuclear Transport of Cofilin in Cultured MyotubesExperimental Cell Research, 1993
- Targeted disruption of the ABP-120 gene leads to cells with altered motility.The Journal of cell biology, 1992