Horner Synthesis of Didehydroamino Acid Derivatives in a Liquid-Liquid Two-Phase System
- 1 January 1988
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1988 (02) , 140-142
- https://doi.org/10.1055/s-1988-27493
Abstract
Horner olefination of aldehydes 1 with N-acyl-2-(diethoxyphosphoryl) glycin ethyl esters 2 to give didehydroamino acid derivatives 3 can be performed advantageously in a 20% aqueous sodium hydroxide/dichloromethane two-phase system in the absence of any typical phase-transfer catalyst.Keywords
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