EFFECT OF VERAPAMIL ON THE CARDIOVASCULAR RESPONSES TO TRACHEAL INTUBATION
Open Access
- 1 January 1992
- journal article
- clinical trial
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 68 (1) , 85-89
- https://doi.org/10.1093/bja/68.1.85
Abstract
We have studied the efficacy of verapamil in attenuating the cardiovascular responses to trachea/ intubation in three groups of ASA grade I patients given verapamil 0.05 mg kg−1 or 0.1 mg kg−1 or saline 45 s before the start of laryngoscopy. Anaesthesia was induced with thiopentone 5 mg kg−1 i.v. and trachea/ intubation was facilitated with vecuronium 0.2 mg kg−1. During anaesthesia, ventilation was assisted or controlled with 1 % enflurane and 50 % nitrous oxide in oxygen. In patients who received saline, there was a significant increase in mean arterial pressure and rate-pressure product associated with tracheal intubation. The increases were significantly less in verapamil-treated patients compared withthose in the control group, although verapamil failed to prevent tachycardia caused by laryngoscopy and intubation.Keywords
This publication has 0 references indexed in Scilit: