Influence of temporary faecal diversion on long-term survival after curative surgery for colorectal cancer

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Abstract
Experimental carcinogenesis is enhanced at colorectal anastomoses, inhibited by proximal faecal diversion and promoted by the closure of a defunctioning stoma. The clinical relevance of these observations was investigated in a retrospective study of curative restorative resection for colorectal carcinoma. The 5‐year disease‐free survival rate (95 per cent confidence interval) in 122 patients with a temporary stoma (50·4 (41·1–59·7) per cent) was significantly reduced (P resection) was associated with a worse survival (P < 0·005) and a higher tumour recurrence rate (P P P = 0·02) and tuning of stoma closure (P = 0·02) as independent predictors of survival. In curative surgery for colorectal cancer temporary faecal diversion confers a survival disadvantage that can be prevented by delayed closure of the stoma.