Casodex (ICI 176,334), A New, Non-Steroidal Anti-Androgen. Early Clinical Results
- 1 January 1989
- journal article
- prostate cancer
- Published by S. Karger AG in Hormone Research
- Vol. 32 (1) , 77-81
- https://doi.org/10.1159/000181316
Abstract
Following promising results in animal studies, Casodex (ICI 176,334) has been studied in the treatment of patients with advanced prostate cancer. At doses of 10, 30 and 50 mg, the drug was found to be well tolerated, with a moderate effect on sex hormone levels. The 50 mg dose of Casodex (daily) reduced previously elevated acid phosphatase levels by 50% or more in 71% of patients.Keywords
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