MICROSOMAL GLUCURONIDATION OF A QUATERNARY AMMONIUM COMPOUND, 3-HYDROXYPHENYLTRIMETHYLAMMONIUM

  • 1 January 1977
    • journal article
    • research article
    • Vol. 5  (1) , 15-18
Abstract
3-Hydroxyphenyltrimethylammonium (HPTMA) [a major metabolite of neostigmine] was glucuronidated in vitro by rat liver microsomes supplemented with UDP-glucuronic acid. Little reaction occurred in the postmicrosomal supernatant fraction. Triton X-100 doubled the maximal velocity for the microsome-catalyzed reaction without altering the apparent Km value for HPTMA. This was the 1st report of glucuronidation of a quaternary ammonium compound in vitro.

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