EFFECT OF EXTRADURAL ANALGESIA USING BUPIVACAINE AND 2-CHLOROPROCAINE ON INTERVILLOUS BLOOD FLOW DURING NORMAL LABOUR

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Abstract
The effect of lumbar extradural analgmig on intervillous blood flow (IBF) during labour was studied in 26 healthy parturients using an i. v. bolus injection of xenon-133. There was a 19% decrease (n.s.) in mean IBF in six parturients (non-extradural control group). Mean IBF increased by 37.5% when 0.25% bupivacaine 10 ml was used and by 35.2% when 2% 2-chloroprocaine 10 ml was used (n.s.). When the two extradural groups were combined, the mean difference between IBFi and IBF2 was 45± 112 ml min dl−1. This increase is statistically significant (P< 0.05). The improvement in IBF after extradural block was considered to be a result of the decreased uterine vascular resistance, as no significant changes were observed in arterial pressure, utenne activity or uterine tone.

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