Modeling Escherichia coli signal peptidase complex with bound substrate: determinants in the mature peptide influencing signal peptide cleavage
Open Access
- 13 February 2008
- journal article
- Published by Springer Nature in BMC Bioinformatics
- Vol. 9 (S1) , S15
- https://doi.org/10.1186/1471-2105-9-s1-s15
Abstract
Type I signal peptidases (SPases) are essential membrane-bound serine proteases responsible for the cleavage of signal peptides from proteins that are translocated across biological membranes. The crystal structure of SPase in complex with signal peptide has not been solved and their substrate-binding site and binding specificities remain poorly understood. We report here a structure-based model for Escherichia coli DsbA 13–25 in complex with its endogenous type I SPase.Keywords
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