Polymorph Leucocyte Function in Uraemia and Jaundice

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Abstract
Biochemical measures of leucocyte function have been examined using cells from patients with jaundice or uraemia in order to elucidate how toxins might affect those cells and vital enzymes such as NADPH oxidase, myeloperoxidase and esterases. Indices of function were depressed in fulminant hepatic failure, in acute uraemia and in some cases of alcoholic cirrhosis. Conversely there seemed to be an adaptive enzyme increase in chronic uraemia and obstructive jaundice. The toxins which affect leucocyte iodination and myeloperoxidase have been defined.