Asymmetric Catalysis with Chiral Ferrocene Ligands
Top Cited Papers
- 29 May 2003
- journal article
- Published by American Chemical Society (ACS) in Accounts of Chemical Research
- Vol. 36 (9) , 659-667
- https://doi.org/10.1021/ar020153m
Abstract
Chiral ferrocene ligands have been widely used in asymmetric catalysis. The advantages of using ferrocene as a scaffold for chiral ligands are described, particularly those regarding planar chirality, rigid bulkiness, and ease of derivatization. The role of planar chirality in 1,2- and 1,1'-disubstituted ferrocene systems is discussed. By using a bulky ferrocene fragment, novel ferrocene ligands were designed, and high enantioselectivity and regioselectivity were achieved in the allylic substitution reaction of monosubstituted allyl substrates. Using the tunable electronic properties of a diphosphine-oxazoline ferrocenyl ligand, the regioselectivity of the intermolecular asymmetric Heck reaction was also examined.Keywords
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