[In vitro suppression of translation of tick-borne encephalitis virus RNA using antisense nucleotides].

  • 1 March 1993
    • journal article
    • abstracts
    • Vol. 27  (2) , 327-34
Abstract
Effect of antisense oligodeoxyribonucleotides on in vitro translation of RNAs corresponding to fragments of the tick-borne encephalitis virus genome has been investigated. Sequences optimal for oligonucleotide binding and translation arrest have been identified. The most efficient oligonucleotide (17-mer) at a concentration of 2.5 microM completely arrests translation of the RNA coding for the NS3 protein.

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