CISPLATIN, VINDESINE, AND BLEOMYCIN (CVB) COMBINATION CHEMOTHERAPY FOR ESOPHAGEAL-CARCINOMA

  • 1 January 1981
    • journal article
    • research article
    • Vol. 65  (9-10) , 781-785
Abstract
Patients (46) with epidermoid carcinoma of the esophagus were treated with a 3-drug combination of cisplatin, vindesine and bleomycin. Of the 40 patients currently evaluable for response, 21 have had partial remissions (52%). At least 4 of these responses were almost complete, with only microscopic disease found on endoscopy or review of the resected specimen. Toxic effects have, in general, been manageable. The major toxic effects included nausea and vomiting, nephrotoxicity and myelosuppression. There were 2 drug-related deaths, 1 due to renal failure and 1 due to sepsis. The 3-drug combination appears to be substantially more effective than the 2-drug combination of cisplatin and bleomycin or vindesine alone. Effects on survival cannot yet be evaluated.

This publication has 0 references indexed in Scilit: