Immunoidiopathic or Immunogenic Thrombocytopenic Purpura

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Abstract
Two decades ago Harrington demonstrated the presence of a humoral antiplatelet factor in patients with idiopathic thrombocytopenic purpura (ITP). Infusion of plasma from patients with ITP into normal persons caused a precipitous fall in the recipient's platelet count.1 Subsequent infusion studies demonstrated that the antiplatelet factor is species specific, has the physicochemical characteristics of an immunoglobulin, and can be adsorbed by autologous or homologous platelets. Although Harrington's studies established that ITP had an immunologic basis, further characterization of the immunologic mechanisms was hindered by the lack of sensitive, specific and reliable methods to detect antiplatelet antibody.Recently, some progress has . . .