Stereochemical course of the reduction of 5α-cholest-8(14)-en-7-one by metal–ammonia; a ready synthesis of 14β-steroids
- 1 January 1973
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 155-161
- https://doi.org/10.1039/p19730000155
Abstract
5α-Cholest-8(14)-en-15-one (III) has been isolated as a by-product of an improved synthesis of 5α-cholest-8(14)-en-7-one (II); the previously undescribed n.m.r. and mass spectra of the former compound are discussed since they are of theoretical interest and diagnostic importance. Whereas reduction of steroidal Δ8(14)15-ketones by metal–ammonia has been known for some time to produce saturated ketones of natural stereochemistry, the corresponding reaction of the isomeric Δ8(14)-7-ketone system has now been shown unexpectedly to generate a ketone of unnatural configuration, and so constitutes a novel and simple synthesis of 14β-steroids.Keywords
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