PRODUCTION OF PROLIFERATIVE LESIONS IN GASTRIC-MUCOSA OF ALBINO MICE BY ORAL-ADMINISTRATION OF N-METHYL-N'-NITRO-N-NITROSOGUANIDINE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 70  (3) , 343-352
Abstract
Gastric adenocarcinoma was produced in 5 of 69 albino mice by oral administration of N-methyl-N''-nitro-N-nitrosoguanidine. Nine other animals that suffered less exposure to this drug presented evidence of typical or atypical hyperplasia, erosion of the mucosa and adenomatous polyp. Intestinal metaplasia was a rare accompanying factor.