The fungal biosynthesis of 3-nitropropionic acid: is the decarboxylation of L-nitrosuccinate an enzymatic reaction?
- 1 January 1994
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 16,p. 2297-2299
- https://doi.org/10.1039/p19940002297
Abstract
In vitro enzymatic hydrolysis of diethyl (RS)-nitrosuccinate 2c by pig liver esterase at pH 7.8 affords 3-nitropropionic acid 1 indicating that the decarboxylation of (RS)-nitrosuccinate 2b is spontaneous under physiological conditions. In the in vivo synthesis of 1 from L-aspartate by cells of Penicillium atrovenetum, which involves oxidation of L-aspartate to nitrosuccinic acid, the decarboxylation of the nitrosuccinate may not require a specific biological catalyst.Keywords
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