MICROBIOLOGICAL DEGRADATION OF BILE ACIDS

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Abstract
Dehydrocholic acid was the sole C source in the culture medium. After growth, 5 fractions were obtained by alumina chromatography of an esterified extract of the medium. Three were unidentified (m. p. 170-182[degree], 202-204[degree], 240-245[degree]C (decomposed) ), but 3,12-dioxo-[DELTA]4,6-choladienic acid (m. p. 172-174[degree]C as ester, absorption peak at 280.5 m[mu]) and 7[alpha]-hydroxy-3,12-dioxo- [DELTA]4-cholenic acid (m. p. 246-249[degree]C (decomposed) or 191-193[degree]C as ester, absorption peak at 241 m[mu]) were identified. The UV absorption curve of the extract of the medium indicated the latter compound as a sole metabolite. The former was presumed to be an artifact arising from the latter during isolation.

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