COMPARATIVE STUDIES ON INFLUENZA-B VIRUS .1. BIOLOGICAL PROPERTIES AND POLYPEPTIDE COMPOSITION OF STRAINS ISOLATED IN DIFFERENT YEARS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 27  (5) , 377-+
Abstract
Influenza B viruses isolated in 1940, 1950 and 1970 belonged to antigenically remote subgroups according to the antigenic composition of their hemagglutinins (HA). Antigenically related strains isolated in 1972-1976 differed in their reproduction capability, sensitivity to inhibitors in mammalian sera and affinity to specific antibodies in human sera. A certain correlation between these properties was observed for strains of the Hong Kong variant. Polyacrylamide gel electrophoresis showed that the viruses under study differed in the mobilities of their major HA chains (HA1). HA1 of the antigenically similar but biologically different influenza B viruses isolated in 1972-1976 had MW varying from 52.5-58 K [kilodaltons]. Neuraminidase (NA) of influenza B/Leningrad/369/75 virus, purified by electrophoresis in acetate cellulose, consisted of 2 polypeptides with apparent MW of 62 K and 57 K. All viruses examined showed similar mobilities of the 57 K NA polypeptide; the mobility of the 62 K polypeptide was similar to that of nucleoprotein.

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