Sexual receptivity in the guinea pig: Inhibitory and facilitatory actions of progesterone and related compounds.

1 January 1967

journal article
Published by American Psychological Association (APA) in Journal of Comparative and Physiological Psychology

Vol. 64 (3) , 378-383
https://doi.org/10.1037/h0025201

Abstract

FOLLOWING TERMINATION OF ESTROGEN-PROGESTERONE-INDUCED RECEPTIVITY, SPAYED GUINEA PIGS WERE REFRACTORY TO FURTHER HORMONAL STIMULATION. REFRACTORINESS DID NOT OCCUR FOLLOWING ESTRUS WHEN ESTROUS BEHAVIOR WAS INDUCED WITH ESTROGEN ALONE, SUGGESTING THAT REFRACTORINESS IS ATTRIBUTABLE TO THE ACTIONS OF PROGESTERONE. UNDER MOST CONDITIONS PROGESTERONE EXERTED A BIPHASIC ACTION, 1ST FACILITATING AND THEN INHIBITING RECEPTIVITY. FOR AT LEAST 1 MEASURE OF RECEPTIVITY THESE ACTIONS OF PROGESTERONE APPEARED TO BE ALL-OR-NONE IN NATURE. A PRINCIPAL METABOLITE OF PROGESTERONE, 20 ALPHA-OH PROGESTERONE, FACILITATED RECEPTIVITY WITHOUT SUBSEQUENTLY DEPRESSING SEXUAL RESPONSIVENESS. THIS SUGGESTS A POSSIBLE DISSOCIATION OF FACILITATORY AND INHIBITORY MECHANISMS OF RECEPTIVITY FOR THIS SPECIES. (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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