Scans (162) of the liver and 160 scans of the brain were performed upon 230 patients with clinical stage I melanoma. None had a true-positive scan. There were 2 false-positive scans of the liver and 2 false-positive scans of the brain. One craniotomy, 2 arteriograms and numerous follow-up scans were done to confirm that these scans were false-positive. The cost of the 322 screening scans was indicated, and the expense of follow-up evaluation was considerably greater. The use of scans of the liver and brain in the evaluation of asymptomatic patients with stage I melanoma was discontinued.