Further Studies on Tetanus Antitoxin Responses in Neonatally Thymectomized Mice

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Abstract
Primary tetanus antitoxin responses were only slightly impaired in neonatally thymectomized specific pathogen-free mice even though time intervals between operation and immunization were greatly extended. Twenty per cent of the thymectomized animals showed severe repression of secondary antitoxin responses; the majority of these animals was unable to respond to a 3rd antigenic stimulation. Newborn mice, injected with concentrated tetanus toxoid shortly before or after neonatal thymectomy, produced tetanus antitoxin and responded to a 2nd injection of antigen of the age of 4 weeks.