False-Positive Reaction to VDRL Test With Prozone Phenomena
- 7 March 1966
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 195 (10) , 868-869
- https://doi.org/10.1001/jama.1966.03100100120044
Abstract
SEROLOGIC TESTS for detection of antibody to treponemata have made it possible to differentiate the patient with treponemal disease from the false-positive reactor to the reagin tests.1 Patients exhibiting such false-positive reactions are often found to have associated infectious or neoplastic or autoimmune diseases.2,3 The highest titer of a standard complement fixation test (Hinton) seen among 200 biologic false-positive reactors in Massachusetts was 1:16.4 The exaggerated production of reagin antibody in 1% to 2% of syphilitics whose disease is in the secondary stage results in a prozone phenomenon.5 The following report concerns a patient with a false-positive, high-titer VDRL (venereal disease research laboratories) microflocculation test with a prozone phenomenon associated with lymphosarcoma. Report of a Case A 66-year-old woman was first seen at the University of California Medical Center in January 1965 because of shortness of breath. In November 1964, a "flu-like" syndrome with chronic coughThis publication has 0 references indexed in Scilit: