Constituents of the Cultivated Mulberry Tree

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Abstract
From the ethyl acetate extract of root bark of the Japanese cultivated mulberry tree (a variety of Morus alba L.), a novel chalcone derivative with a fused dihydrochalcone partial moiety was isolated and named kuwanon I. The structure was shown to be I on the basis of chemical and spectral data. Kuwanon I (I) is the first example which is regarded biogenetically as a Diels-Alder adduct of a prenylchalcone derivative and a dehydroprenylchalcone derivative. NMR variable temperature studies of I suggested that kuwanon I (I) exists as an equilibrium mixture of conformational isomers in solution. 1 Part IX: Nomura, T., Fukai, T. and Hano, Y., Planta medica submitted. 2 Part of this work was presented at the 101th Annual Meeting of the Pharmaceutical Society of Japan, Kumamoto, April, 1981.