HEMODYNAMIC EFFECTS OF ADENOSINE-5'-CARBOXYLIC ACID-AMIDE IN ANESTHETIZED DOG DURING NORMAL RESPIRATION AND HYPERCAPNIC ACIDOSIS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 219  (1) , 140-148
Abstract
Adenosine-5''-carboxylic acid-amide (1 .mu.g/kg/min) and adenosine (500 .mu.g/kg/min), given in a 10 min i.v. infusion to anesthetized dogs, produced qualitatively and quantitatively comparable cardiovascular effects, namely a marked increase in coronary blood flow and a generalized vasodilation, concomitantly with an increase in heart rate, left ventricular dp/dt [change of pressure with time], heart work, myocardial O2 consumption, and pulmonary blood pressure; the pulmonary vascular resistance remained unchanged. Hypercapnic acidosis enhanced the coronary dilator effect of both compounds. Adenosine and adenosine-5''-carboxylic acid-amide act at the same receptor sites.