cIAP‐1, but not XIAP, is cleaved by caspases during the apoptosis induced by TGF‐β in fetal rat hepatocytes
- 14 May 2002
- journal article
- Published by Wiley in FEBS Letters
- Vol. 520 (1-3) , 93-96
- https://doi.org/10.1016/s0014-5793(02)02774-6
Abstract
We have studied the expression of XIAP, cIAP‐1 and cIAP‐2 in fetal rat hepatocytes and its possible regulation by pro‐apoptotic stimuli (transforming growth factor‐β (TGF‐β)) and survival signals (epidermal growth factor (EGF)). The three forms of inhibitor of apoptosis proteins (IAPs) are expressed in fetal hepatocytes and only cIAP‐1, but not XIAP or cIAP‐2, is cleaved during TGF‐β‐induced apoptosis. The pan‐caspase inhibitor Z‐VAD.fmk blocked this effect, which indicates that cIAP‐1 is a caspase substrate. EGF plays a dual role in the regulation of IAPs expression. On one hand, it increases cIAP‐1 and cIAP‐2 basal expression and, on the other hand, it blocks the cleavage of cIAP‐1 by caspases induced by TGF‐β.Keywords
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