CLINICAL EVALUATION OF SERUM C3DP LEVELS IN INDIVIDUALS WITH MALIGNANT DISEASES

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (3) , 692-695
Abstract
A human serum DNA binding protein (C3DP) derived from complement component C3 was found in elevated concentrations in the sera of individuals with malignant diseases. An assay system was devised which reveals quantitative values of serum C3DP levels. Results obtained using this system indicate that normal human sera have an average C3DP level of 83 .mu.g/ml (range, 40-146); sera from individuals with active carcinomas have an average C3DP level of 242 .mu.g/ml (range, 146-400). Sera from individuals with active leukemias, lymphomas and melanomas had elevated levels of C3DP; sera from individuals with polycythemia vera or nonmalignant diseases had normal or only slightly elevated C3DP concentrations. No tissue specificity seems to be required for malignant growths to result in elevated C3DP serum concentrations. The levels of C3DP in 79% of individuals who experienced disease remission declined to normal values, concurrent with disease regression. Patients who did not respond to therapy regimens retained high C3DP levels.

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