Inhibitions by Tetracycline and Oxytetracycline of the Consumption of Pyruvate by Aerobacter Aerogenes

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Abstract
The effects of tetracycline and oxytetracycline on the production of pyruvate and on its utilisation by a strain of Aerobacter aerogenes in glucose-mineral salt media, have been examined. Both antibiotics inhibit the production of formate from pyruvate by non-proliferating suspensions of cells in unaerated, but not in aerated media. The only acidic material accumulated during growth is formic acid and the cessation of growth coincides with the concentration of undissociated formic acid reaching 0·2 mM and 0·3 mM respectively in unaerated and aerated media. At the end of the growth phase of unaerated cultures the reproduction of cells is replaced by the production of lactic acid. The possibility of a common primary site of inhibition being responsible for inhibition of pyruvate and mode II inhibition of growth (Jones and Morrison, 1962) is discussed.

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