Bacterial and phage mutations that reveal helix-unwinding activities required for bacteriophage T4 DNA replication.
- 1 March 1983
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 80 (6) , 1669-1673
- https://doi.org/10.1073/pnas.80.6.1669
Abstract
An Escherichia coli strain with a mutation in the optA gene restricts the growth of bacteriophage T4 strains partially defective in gene 43 (DNA polymerase) or missing gene dda (DNA-dependent ATPase). The mutations in the dda gene inactivate a DNA-dependent ATPase that has been shown to have DNA helicase activity in vitro. The restriction of phage growth after infection of the optA bacterium is the result of a block in DNA replication. Evidently, the block arises from a defect in DNA unwinding.This publication has 35 references indexed in Scilit:
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