Different Potencies of Biosynthetic Human and Purified Porcine Insulin

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Abstract
The glucose clamp technique was used to compare the biological activity of purified porcine insulin and Biosynthetic Human Insulin (BHI). An intravenous bolus of 0.1 U/kg BW was injected in eight male volunteers, and the glucose was clamped at baseline values (euglycemic clamp). Serum insulin, serum C-peptide and plasma glucose did not differ between porcine and human insulin. The insulin induced glucose consumption differed significantly (p less than 0.007) between purified porcine insulin (50.5 +/- 5.2 [SEM] g/2h) and Biosynthetic Human Insulin (63.5 +/- 4.5 g/2h). Purified porcine insulin induced a hormonal response with significantly (p less than 0.05) elevated concentrations of serum growth hormone (12.1 +/- 0.25 ng/ml) and serum cortisol (161.4 +/- 28.6 ng/ml), which were not observed following Biosynthetic Human Insulin (serum growth hormone: 2.6 +/- 0.2 ng/ml; serum cortisol: 117.3 +/- 14.8 ng/ml). The data confirm earlier results indicating hormonal and metabolic differences between human and porcine insulin.

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