A fluorescence polymorphism associated with Down's syndrome?

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Abstract
Fluorescence polymorphism frequencies were determined for a group of 85 Down''s syndrome cases and 164 controls. For 1 class of polymorphism, that of positive satellites of chromosome 21, the frequency in the Down''s cases was significantly higher than in the controls; the distribution of positive satellites in the mongols indicates that in the majority the extra chromosome arose by 1st meiotic non-disjunction. The possibility that positive satellites on chromosome 21 could be a causative factor in Down''s syndrome is discussed, and the implications of this possibility on the assessment of the risk of producing a Down''s child are examined.