Effects of Four Restricted Liquid Diet Regimens and One Nonrestricted Solid Diet Regimen on Enzyme Activities Associated with Hepatic Drug Metabolism

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Abstract
Two different nutritionally adequate liquid diets containing either 18% protein, 47% carbohydrate and 35% lipid, or 18% protein, 12% carbohydrate and 70% lipid were given to rats once daily or in 4 divided doses for 3 wk. The liquid diets decreased hepatic protein content and concentration and the activities of hepatic .gamma.-glutamyl transferase and NADPH cytochrome c reductase, compared to a zero time group fed chow and water. There were no important differences between the treatment groups. Aniline hydroxylase activity was also decreased by the liquid diets, but the high-lipid diet decreased the activity significantly less than the high-carbohydrate diet. Rats fed chow and water ad lib for 3 wk were less different from the zero time value than rats in any of the liquid diet groups. The effects of liquid diets may be important in alcohol research, where a high-carbohydrate liquid diet in restricted amounts is widely used for feeding the control animals.

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