Adenosine triphosphatase activities in brain, kidney and liver of mice treated with toxaphene

Publisher Website
Google Scholar
Abstract
The sensitivity of Na+-K+ and Mg2+ ATPases in mouse tissues to toxaphene, a highly chlorinated camphene insecticidal mixture, was determined in vivo and in vitro. The brain and kidney Na+-K+ ATPase activities were significantly inhibited in vitro by toxaphen. The inhibition was not significantly increased with an increase in the concentration of toxaphene. The oligomycin-sensitive (mitochondrial) Mg2+ ATPase activities in mouse brain, kidney and liver fractions were significantly inhibited by toxaphene in a concentration-dependent fashion. The oligomycin-insensitive Mg2+ ATPase in all tissues examined was inhibited but less sensitive to toxaphene than mitochondrial Mg2+ ATPase. In contrast to in vitro response, the brain ATPases were not altered in mice fed toxaphene by oral intubation for 3 days. The renal and hepatic ATPase activities were significantly decreased in toxaphene treated mice with the oligomycin-insensitive Mg2+ ATPase activity being only slightly altered.